Unfavorable changes in the intestinal flora (dysbiosis) are able to determine an alteration of the ideal homeostatic balance which favors the regular function of the intestinal barrier.
A deterioration of this balance causes the passage of macromolecules contained in the intestinal lumen towards the underlying tissues and therefore in the bloodstream, with a consequent activation of the immune response and the induction of a systemic inflammatory state.
These mechanisms are able to support the production of pro-osteoclastogenic cytokines, to stimulate bone resorption and overall cause a loss of bone density.
PER BONE is a food supplement capable of restoring the physiological function of the intestinal barrier and flora, of enhancing the optimal permeability of the mucosa and improving the balance and maintenance of the intestinal anatomical-microbiological barrier, positively promoting the mechanisms of remodulation and regeneration bone density.
- Inulin, an indigestible oligosaccharide, which is an excellent substrate for colon microflora, has an excellent functional effect on gastrointestinal physiology and the immune system, promoting the growth of favorable microbial species with fundamental anti-inflammatory functions.
- Lactobacillus rhamnosus which helps to replenish the optimal composition of the intestinal flora, triggering multiple strain-specific activities, including immune modulation, the elimination of pathogenic enterobacteria, the stimulation of mucus production, the growth and maturation of enterocytes with a improvement of intestinal permeability and a consequent reduced production of pro-osteoclastogenic cytokines, thus preventing the loss of bone density.
- Vitamin D which guarantees adequate vitality and balance of the intestinal and systemic immune response, controlling the general inflammation status, determining better control of mucosal permeability and modulating the physiological mechanisms that control bone density.
- Vitamin K2 which is also produced by a healthy intestinal flora and plays a synergistic protective role with vitamin D in a wide spectrum of biological functions with a crucial control of the phenomena of regeneration and modulation of bone density.